Saha Institute of Nuclear Physics has been working in different branches of theoretical and experimental disciplines of biophysical sciences since the early fifties. Under the inspiration and active support of the visionary Prof. Meghnad Saha, one of the oldest schools of Biophysics in India was formed. An electron microscope, the first of its kind in Asia, was fabricated indigenously in the institute under the able stewardship of Prof. N. N. Dasgupta. Since then, pioneering work was done on microscopic characterization of infectious microorganisms, cellular architectures and Radiation Biology. Subsequently, research in various fields of Structural Biology and Spectroscopy was initiated to understand the interactions of the biologically important molecules. In the post genomic era, the immense potential of the area where physics meets biology, led to the formation of a new division- “Biophysics & Structural Genomics” in 2013. Our scientists are now actively involved in interdisciplinary area of basic and clinical research - Proteomics, Biomolecular Recognition: Chemical and Structural Biology, in silico and synthetic biology.