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Dr. Nabi is Professor and Director of Imaging in the Life Sciences Institute
of the University of British Columbia in Vancouver, Canada with almost
30 years of cell biology experience in the field of cellular domains and
their role in cancer progression and metastasis. As a graduate student, he
identified the Gp78 receptor of autocrine motility factor and has gone on to
define its dual roles as a cell surface receptor and endoplasmic reticulum
(ER) associated E3 ubiquitin ligase, more recently defining its role as a
regulator of ER-mitochondria contacts and showing that Gp78 basal mitophagy
controls cancer cell ROS. His work has also focused on the characterization
of cell surface domains, including lipid rafts, caveolae and non-caveolar
caveolin-1 scaffolds and the galectin lattice and their regulation of focal
adhesion dynamics and tension in cancer cell migration and metastasis. He will
discuss his recent work that has focused on applying computational machine
learning approaches to super-resolution microscopy to decipher the molecular
structure of caveolae and scaffolds, the nanodomain structure and dynamics of
the ER as well as mitochondria-ER contact sitesand autophagosome maturation
in cancer cells.
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