Research Areas: Mass Spectrometry, Metabolomics, Epitranscriptomics, Exposomics, Cancer, Environmental Health, and Personalized Medicine.
Our lab is interested in characterization of changes in metabolomic, proteomic (especially, post-translational modifications related to metabolism) and epitranscriptomic (endogenous RNA modification) signatures associated with gene-environment interaction and pathogenesis. Mass spectrometry and complementary analytical techniques are used as the tool for analyzing these changes in matrices of interest (biofluid, tissue, cell and organelle). Changes in metabolite distribution and gene expression patterns are combined to elucidate the system-level reorganization of molecular networks. The ultimate aim is to develop these signatures as biomarkers for personalized medicine and to identify target pathways to manipulate the outcome of gene-environment interaction and pathogenesis. We are also developing sensors for metabolites, which could eventually be used for real-time sub-cellular imaging of changes in metabolite distribution.
Our interests include nutrition and child health, metabolic disorders, hepatobiliary diseases, cancer, radiation response and host-microbiome interaction. Along with cellular, molecular biological and biophysical approaches as well as studies involving animal model and patient samples, we invest in
- Chromatography and mass spectrometry.
- Chemoinformatics, bioinformatics and statistics.
- Synthesis and characterization of novel metabolites, sensors
- Elucidation of their biochemical origin and physiological importance.
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