Mr. Manas Mondal

Research

Research Experience:  Explored nucleic acids through Molecular Dynamics and simulations.  Investigated non-covalent interactions by quantum chemical studies.  Facilitated structural analysis, modeling of biomolecules.  Explore the mode of biomolecular recognition and protein-DNA interaction through molecular dynamics simulation.  Investigation of preferred geometry of nucleic acid sequences through Coarse Grain Modeling and Monte Carlo Simulation.  Research Interest:   Biological systems are mainly governed by the interactions among the several macromolecules in a regulated manner. Among the several macromolecular interactions, protein-DNA, protein-protein and protein-ligand interactions are very important which control the most of the complex biological processes within a living cell. I would like to extend my experience with biomolecules and work on structure and dynamics of proteins and protein-nucleic acid, protein-protein and protein-small molecule interaction. Using Molecular modeling and simulation techniques, my goal is to understand the important macromolecular interactions and its implications, which are not well studied. I am also intersted to explore the thermodynamics of the macromolecules in biomolecular interactions and recognition mechanism. For study the short range interactions and electron transfer mechanism in macromolecular interactions use of ab-initio quantum chemical approaches is also my further interest. In a broad sense I am interested in understanding the macromolecular basis in biological system by studying their structure, dynamics and interactions and the correlation among them with biochemical function.