• Protein Crystallography

  • Molecular Recognition

  • Protein Engineering & Enzyme Biotechnology

  • M. Sc. in Chemistry, (1987-1989), University of Burdwan

  • Post M. Sc. Associate-ship Diploma in Bioscience (1990-1991), Saha Institute of Nuclear Physics

  • Ph. D. in Protein Crystallography (1991-1997),Saha Institute of Nuclear Physics

  • Post-Doctoral Fellowship (1998- 2000), The Scripps Research Institute, La Jolla, CA, USA

  • Post-Doctoral Fellowship (2007), University of Southern California, USA

 

Recent Publications:

  1. Banerjee M, Majumder P, Bhattacharyya NP, Dattagupta JK, Sen U (2006). Cloning, expression, purification, crystallization and preliminary crystallographic analysis of pseudo death-effector domain of HIPPI, a molecular partner of Huntingtin-interacting protein HIP-1. Acta Cryst F. Dec 1;62(Pt 12):1247-50.

  2. Jhimli Dasgupta, Susmita Khamrui, Jiban K Dattagupta and Udayaditya Sen (2006).  Spacer Asn determines the fate of Kunitz (STI) inhibitors, as revealed by the structural and biochemical studies on WCI mutants.  Jun 6;45(22):6783-92.

  3. Subhasree Roy Choudhury, Aparna Gomes , Antony Gomes, Jiban K Dattagupta and Udayaditya Sen (2006). Purification, crystallization and preliminary X-ray structural studies of a 7.2 kDa cytotoxin, isolated from the venom of Daboia russelli russelli of Viperidae family. Acta Cryst. F. 62, 292-294.

  4. Susmita Khamrui, Jhimli Dasgupta, Jiban K Dattagupta and Udayaditya Sen   (2005)   Single mutation at P1 of a chymotrypsin inhibitor changes it to a trypsin inhibitor: X-ray structural (2.15 �) and biochemical  basis. Biochimica et Biophysica Acta-proteins and proteomics, 1752: 65-72

  5. Udayaditya Sen, Jhimli Dasgupta, Debi Choudhury, Poppy Datta, Abhijit Chakrabarti, Sudipa Basu Chakrabarty, Amit Chakrabarty and Jiban K Dattagupta, (2004) Crystal structures of HbA2 and HbE and modeling of Hemoglobin d4: interpretations of the thermal stability and the antisickling effect of HbA2. Biochemistry 43(39), 12477-88.

  6. Debashis Mukhopadhyay*, Udayaditya Sen*, James Zapf and Kottayil I. Varughese, (2004) Metals in the sporulation phosphorelay: manganese binding by the response regulator SpoOF. Acta Crystallographica D, 60(4), 638-45.

  7. Jhimli Dasgupta, Udayaditya Sen and J.K.Dattagupta (2003) In-silico mutations and molecular dynamics studies on a Winged bean Chymotrypsin Inhibitor protein. Protein Engineering, 16(7), 489-96.

  8. Jhimli Dasgupta, Udayaditya Sen, Debi Choudhury, Poppy Datta, Abhijit Chakrabarti, Sudipa Basu Chakrabarty, Amit Chakrabarty and J.K. Dattagupta (2003) Crystallization and preliminary X-ray structural studies of Hemoglobin A2 and Hemoglobin E, isolated from the blood samples of Beta-thalassemic patients.  Biochemical and Biophysical Research Communications, 303, 619-623.

  9. Debi Choudhury, Piyali Guha Thakurta, Rakhi Dasgupta, U.Sen, S. Biswas, C. Chakrabarti and J.K. Dattagupta (2002) Purification and Preliminary X-ray Studies on Hen Serrotransferrin in Apo- and Holo- form. Biochemical and Biophysical Research Communications, 295, 125-128.

  10. Udayaditya Sen, Sona Vasudevan, Gowtham Subbarao, Richard A. McClintock, Reha Celikel, Zaverio M. Ruggeri and Kottayil I. Varughese, (2001) Crystal Structure of the von Willebrand Factor Modulator Botrocetin. Biochemistry, 40(2), 345-52.

  11. Zapf J*, Sen U.*, Madhusudan, Hoch J. A and Varughese K. I. (2000) A transient interaction between two phosphorelay proteins trapped in a crystal lattice reveals the mechanism of molecular recognition and phosphotransfer in signal transduction. Structure Fold Des. 8(8), 851-62.

  12. Udayaditya Sen, James Zapf, Madhusudan, James A. Hoch and Kottayil I. Varughese (2000) Molecular Recognition and Phosphotransfer Between Two Phosphorelay Proteins. Protein Science, 9(Supple 1), pp 143.

  13. K. I. Varughese, U. Sen, J. Zapf, Madhusudan, J. A Hoch and (1999) A complex of a phosphotransferase and response regulator: The mechanism of phosphoryl transfer in a phosphorelay. American Crystallographic Association (ACA) meeting, pp 40.

  14. Ravichandran S., Sen U., Chakrabarti C and Dattagupta JK. (1999) Cryocrystallography of a Kunitz-type serine protease inhibitor: the 90 K structure of winged bean chymotrypsin inhibitor (WCI) at 2.13 � resolution. Acta Crystallogr,  D55(11),1814-21.

  15. Dattagupta JK, Podder A, Chakrabarti C, Sen U., Mukhopadhyay D, Dutta Samir K and Singh M., (1999) Refined Crystal Structure (2.3 �) of a Double-Headed Winged Bean a-Chymotrypsin Inhibitor and Location of Its Second Reactive Site. Proteins: Structure, Function and Genetics,35(3), 321-331.

  16. Dattagupta JK, Podder A, Chakrabarti C, Sen U., Dutta Samir K and Singh M. (1996) Structure of a Kunitz-type Chymotrypsin Inhibitor from Winged bean seeds at 2.95� resolution. Acta Crystallographica , D52, 521-528.

  17. Dattagupta JK, Podder A, Chakrabarti C, Sen U., Dutta S K and Singh M. (1993) Crystal structure of Psophocarpin B1: A chymotrypsin inhibitor from Winged bean seeds, Acta Crystallographica, A49, pp. 122.

  18. J. Dasgupta, S. Ravichandran, D. Mukhopadhyay, U.Sen, A. Podder, C. Chakrabarti and J.K.    Dattagupta (1999).  A Serine Protease Inhibitor Protein : From X-ray Structure to Protein Engineering.   In Volume  published in honour of Prof. G.N. Ramachandran during International Biophysics Congress at New Delhi in September, 1999. Book name: �Perspectives in Structural Biology� Editors:M.Vijayan, N.Yathindra, A.S.Kolaskar, Page 75-82.

  19. Udayaditya Sen, Sampa Biswas, Chandana Chakrabarti and J. K. Dattagupta (2005) Structure-function of a few plant proteins using X-ray crystallography. Frontiers in Biophysics: Vol. 6, Indian Journal of Physics - Special Issue, Eds. T.P.Singh & C.K.Dasgupta, Allied Publishers Pvt. Ltd. Pages 50-66.

  20. Dattagupta,J.K.,Podder,A.,Chakrabarti,C.,Sen,U.,Dutta,S. and Singh,M. (1997) Crystal Structure of Psophocarpin B1: A  chymotrypsin inhibitor from winged bean seeds.  `Aspects of  Crystallography  in  Molecular Biology',  S. Parthasarathy and  J. Glusker  (eds.). New Age International Publishers. pp 287-291.

Contact: udayaditya.sen[at]saha.ac.in

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