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Main area of our interest is to understand how the
immune disorder leads to the opportunistic proliferation advantage and
differentiation abilities in hematological malignancies. Studies on immune
modulation of the leukemia cells to understand the structure function
correlation of MHC regulatory transcription factors (viz. CIITA, RFX
complex, CREB, NF-complex etc) in an interdisciplinary approach is underway
to design immunotherapeutic modalities. We are also investigating the
aberrant gene expression pattern of CD34+ Leukemia Stem Cells with a view to
design an effective viral based gene transfer vector to target leukemic
cells.
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Ph.D.: Saha Institute of Nuclear Physics, 1991
Post Doc: University of North Carolina at Chapel Hill, NC, US
Fanconi’s Anemia Post Doctoral Fellowship, USA 1992-1995
Leukemia Society of America Fellowship, USA 1995-1997
Head, Structural
Genomics Section
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Basu U & Banerjee S: An
engineered EBV vector expressing human factor VIII and von Willebrand factor
in cultured B-cells. J Gene Med. 2004 Jul;6(7):760-8.
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Majumder D, Bandyopadhay D, Chandra S,
Mukhopadhyaya A, Mukherjee N, Bandyopadhyaya S & Banerjee S: HLA class Ia
transcripts in human leukaemias. Immunogenetics. 2005 Sep;57(8):579-89.
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Majumder D, Bandyopadhaya D, Chandra S, Mukherjee N & Banerjee S: Lack of
HLA-E surface expression is due to deficiency of HLA-E transcripts in the
malignant hematopoietic cells of leukemic patients.
Leuk Res. 2006 Feb;30
(2):242-5.
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Dutta N, Majumder D, Gupta A, Majumder DN &
Banerjee S: Analysis of human lymphocyte antigen class I expression in
gastric cancer by reverse transcriptase-polymerase chain reaction. Hum
Immunol. 2005 Feb;66(2):164-9.
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Dutta N, Gupta A, Majumder DN & Banerjee S:
Downregulation of locus specific Human Lymphocyte Antigen class I expression
in Epstein Barr Virus associated Gastric cancer: Implications for viral
induced immune evasion. Cancer 2006 106(8):1685-93.
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Sengupta A, Banerjee D, Chandra S, Banerjee S. Gene therapy of BCR-ABL(+)
human CML with dual phosphorylation resistant p27(Kip1) and stable RNA
interference using an EBV vector. J Gene Med 2006; 8:1251-1261.
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Sengupta A, Banerjee D, Chandra S, Banerji SK, Ghosh RN, Roy R, Banerjee
S. Deregulation and cross talk among Sonic hedgehog, Wnt, Hox and Notch
signaling in chronic myeloid leukemia progression. Leukemia 2007; 21: 949 -
955.
- Amitabha Sengupta
& Subrata Banerjee. "Pleiotropic p27 (kip1),BCR-ABL & Leukemic Stem Cells:
The trio in concert". Leukemia (2007) July 5 ; [Epub ahead of print]
Contact:subrata.banerjee[at]saha.ac.in
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