Head, C & MB Division

Faculty Member                       1994- till date   SINP

Research Associate                  1992-1994       University of Utah, U. S.A

Research Associate                  1991-1992       Imperial Cancer Research Fund, London

Visiting fellow                           1989-1991       SINP

Research Associate                  1986-1989       Michigan State University, U. S. A.

Ph.D.                                       1986                Calcutta University

Journals

1. Swasti Raychaudhuri, Mithun Sinha, Debashis Mukhopadhyay, N.P. Bhattacharyya. "HYPK, a huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal huntingtin with 40 glutamines in Neuro2A cells and exhibits chaperone like activity". Hum Mol Genet. 2007 Oct 18; [Epub ahead of print]

2. Sucharita Dey, Swasti Raychaudhuri, N. P. Bhattacharyya & Debashis Mukhopadhyay. “The Role of Intrinsically Disordered Proteins In Neurodegenerative Diseases”.Annals of Neurosciences (2007), Vol. 14 (Suppl.), 58-59. (Abstract only)

3. Majumder P, Choudhury A, Banerjee M, Lahiri A, Bhattacharyya NP.Interactions of HIPPI, a molecular partner of Huntingtin interacting protein HIP1, with the specific motif present at the putative promoter sequence of the caspase-1, caspase-8 and caspase-10 genes. FEBS J. 2007, 274(15):3886-99.

4. Pritha Majumder, Swasti Raychaudhuri, Biswanath Chattopadhyay, N.P. Bhattacharyya. "Increased Caspase-2, Calpain Activations and Decreased Mitochondrial Complex II Activity in Cells Expressing Exogenous Huntingtin Exon 1 Containing CAG Repeat in the Pathogenic Range".  Cell Mol Neurobiol. 2007 Sep 28; [Epub ahead of print]

5. Swasti Raychaudhuri, Pritha Majumder, Somosree Sarkar, Kalyan Giri, Debashis Mukhopadhyay and Nitai P. Bhattacharyya. "INTRINSICALLY UNSTRUCTURED proteins in Huntington’s disease - HYPK: a case study".  Proteins: Structure, Function & Bioinformatics (2007); (In Press)

6. Majumder P, Chattopadhyay B, Sukanya S, Ray T, Banerjee M, Mukhopadhyay D,  Bhattacharyya NP  (2007) Interaction of HIPPI with putative promoter sequence of caspase-1 in vitro and in vivo.Biochem Biophys Res Commun , 353, 80-85.

7. Banerjee M, Majumder P, Bhattacharyya NP, Dattagupta JK, Sen U. (2006) Cloning, expression, purification, crystallization and preliminary crystallographic analysis of pseudo death-effector domain of HIPPI, a molecular partner of Huntingtin-interacting protein HIP-1, Acta Crystallograph Sect F Struct Biol Cryst Commun. 62, 1247-1250.

8. Majumder P, Chattopadhyay B, Mazumder A, Das P, Bhattacharyya NP (2006). Induction of apoptosis in cells expressing exogenous Hippi, a molecular partner of huntingtin-interacting protein Hip1.Neurobiol Dis. 22, 242-56.

9. Giri K, Bhattacharyya NP, Basak S.  (2007) pH-dependent self-assembly of polyalanine peptides. Biophys J. 92, 293-302.

10. Ghosh U, Das N, Bhattacharyya NP. (2007) Inhibition of telomerase activity by reduction of poly(ADP-ribosyl)ation of TERT and TEP1/TP1 expression in HeLa cells with knocked down poly(ADP-ribose) polymerase-1 (PARP-1) gene. Mutat Res. 615, 66-74.

11. Mukherjee Nee Chakraborty S, Ghosh U, Bhattacharyya NP, Bhattacharya RK, Dey S, Roy M. (2007) Curcumin-induced apoptosis in human leukemia cell HL-60 is associated with inhibition of telomerase activity, Mol Cell Biochem., 297, 31-39.

12. Roychoudhury P, Ghosh U, Bhattacharyya NP, Chaudhuri K., (2007) Activation of mitochondrial promoter P(H)-binding protein in a radio-resistant Chinese hamster cell strain associated with Bcl-2. Biochem Biophys Res Commun. 350, 272-276

13. Chakraborty S, Ghosh U, Bhattacharyya NP, Bhattacharya RK, Roy M. (2006) Inhibition of telomerase activity and induction of apoptosis by curcumin in K-562 cells, Mutat Research. 596, 81-90

14.  Baksi K, Bhattacharyya NP. (2005)  Polymorphic amino acid substitutions in proteins; Substitution of polymorphic amino acids in proteins: Predicting functional alterations using amino acid properties. Online Journal of Bioinformatics, 6, 42-50

15. Chattopadhyay B, Baksi K, Mukhopadhyay S, Bhattacharyya NP.  (2005) Modulation of age at onset of Huntington disease patients by variations in TP53 and human caspase activated DNase (hCAD) genes. Neurosci Lett. 374:81-86

16. Ghosh U, Bhattacharyya NP (2005) .Benzamide and 4-amino 1,8 naphthalimide treatment inhibit telomerase activity by down-regulating the expression of telomerase associated protein and inhibiting the poly(ADP-ribosyl)ation of telomerase reverse transcriptase in cultured cells. FEBS J. 272 4237-4248.

17. Rengaraj R, Dhanaraj M, Arulmozhi T, Chattopadhyay B, Battacharyya NP (2005) High prevalence of spinocerebellar ataxia type 1 in an ethnic Tamil community in India. Neurology India, 53, 308-310

18. MacPherson G, Healey CS, Teare MD, Balasubramanian SP, Reed MW, Pharoah PD, Ponder BA, Meuth M, Bhattacharyya NP, Cox A (2004) Association of a common variant of the CASP8 gene with reduced risk of breast cancer. J Natl Cancer Inst., 96, 1866-1869.

19. Bhattacharyya KB, Sengupta P., Basu N  and Bhattacharyya NP (2004) Becker’s variety of myotonia congenital in two siblings: a clinico-genetic study. Neurology India, 52, 363-364

20. Biswanath Chattopadhyay, Sabari Gupta, Prasanta K. Gangopadhyay,   Shaymal K. Das, T. Roy, Subhash C. Mukherjee, Krishna K. Sinha5, Bhim S. Singhal, Bhattacharyya N.P (2004) Molecular analysis of GAA repeats and four linked bi-allelic markers in and around frataxin gene among patients and normal populations from India, Annals of Human genetics, 68, 189-195

21. Chaudhuri K, Banerjee R, Pandit B, Mukherjee A, Das S, Sengupta S, Roychoudury S and  Bhattacharyya N.P (2003)  Identification of two differentially expressed mitochondrial genes in a methotrexate resistant Chinese hamster cell strain derived from V79 cells using RNA finger printing by arbitrary primed polymerase chain reaction (RAP-PCR),   Radiation Research, 160, 77-85.

22. Giri K, Ghosh U, Bhattacharyya N.P., Basak S. (2003) Caspase 8 mediated apoptotic cell death induced by beta-sheet forming polyalanine peptides, FEBS Lett., 555, 380-384

23. Chattopadhyay B, Basu P, Gangopadhyay PK, Mukherjee SC, Sinha KK, Chakraborty A, Roy T, Roychoudhury S, Majumder P, Bhattacharyya N.P. (2003) Variation of CAG repeats and two intragenic polymorphisms at SCA3 locus among Machado-Joseph disease/SCA3 patients and diverse normal populations from eastern India, Acta Neurol Scand. 108, 407-414

24. Basu A, Mukherjee N, Roy S, Sengupta S, Banerjee S, Chakraborty M, Dey B, Roy M, Roy B, Bhattacharyya N.P., Roychoudhury S, Majumder PP (2003) Ethnic India: a genomic view, with special reference to peopling and structure, Genome Res. 13, 2277-2290

25. Chattopadhyay, B., Gangopadhyay, PK, Das SK, Roy T, Sinha SK, Jha DK, Mukherjee SC, Chakraborty, A, Singhal BS, Bhattacharya, AK  and  Bhattacharyya  N.P. (2003) Modulation of age of onset in Huntington’s disease and spinocerebellar ataxia type 2 patients originated from eastern India, Neuroscience Letters, 345, 393-396

26. Mitra S, Chatterjee S, Panda CK, Chaudhuri K, Ray K, Bhattacharyya N.P, Sengupta A, Roychoudhury S (2003) Haplotype structure of TP53 locus in Indian population and possible association with head and neck cancer, Ann Hum Genet, 67, 26-34

27. Pandit B. and Bhattacharyya N.P. (2001) In vitro and in vivo inhibition of telomerase activity from Chinese hamster V79 cells, Indian Journal of Biochemistry and Biophysics, 38, 42-47

28. Basu P., Majumder P. P., Roychoudhury S. and Bhattacharyya N.P. (2001) Haplotype analysis of genomic polymorphisms in and around the myotonic dystrophy locus in diverse populations of India, Human Genetics, 108, 310-317

29. Chakraborti Susmita,  Dasgupta Santanu, Roy Sangita, Bhar Anusree, Sengupta Arunava, Roy Anup, Ray Kunal, Bhattacharyya N. P, Roy Bidyut, Panda Chinmay K. and Roychoudhury Susanta (2001) Microsatellite Instability in Squamous Cell Carcinoma of Head and Neck from the Indian Patient Population, Int. J. Cancer , 92, 555-561.

30. Basu P., Chattopadhyay B., Gangopadhaya P.K Mukherjee S.C., Sinha K.K., Das.S.K., Roychoudhury S. and Majumder P. P.  and  Bhattacharyya N.P. (2000) Analysis of CAG repeats in SCA1, SCA2, SCA3, SCA6, SCA7 and  DRPLA loci among spinocerebellar ataxia patients and distribution of CAG repeats at the SCA2 and SCA6 loci in nine ethnic populations of eastern India, Human Genetics, 106, 597-604

31. Basu P.,  Gangopadhaya P.K Mukherjee S.C., Das.S.K., Sinha K.K., and Bhattacharyya N.P. (2000) Molecular anatomy of CTG expansion in Myotonin Protein kinase Gene among Myotonic Dystrophy Patients from Eastern India, Human Mutaion, Mutaion in Brief #369 online

32. Pramanik S. Basu P.,  Gangopadhaya P.K., Sinha K. K., Jha D.K., Sinha S., Das S.K., Maiti B. K.,  Mukherjee S.C.,  Roychoudhury S. and Majumder P. P. and Bhattacharyya N.P. (2000) Analysis of CAG and CCG repeats in Huntingtin gene among HD patients and normal populations of India, European Journal of Human Genetics, 8, 678-682

33. B. Ghosh, Gangopadhyay, P.K., Saha, S., Guha, D., Das, S., Roy, T., Basu, N., Basu, P. and Bhattacharyya, N. P. (2000) Genetic study of adult onset inherited progressive ataxia, JANEI, 5, 51-54.

34. Sengupta, S, Roy, M. and Bhattacharyya, N.P. (2000) Effect of post AK-2123 treatment in aerobic condition on cell killing in a radioresistant cell strain derived from V79 cells, IACT scientific report

35. Bhattacharyya , N.P., Basu P., Das M., Pramanik S., Banerjee S., Roy B. Roychoudhury S. and Majumder P. P. ( 1999 ) Negligible male gene-flow across ethnic boundaries in India, revealed by analysis of Y-chromosomal DNA polymorphisms. Genome Research, 9, 711 – 719

36. Basu  P, Ganguly  PK , Basu  D and Bhattacharyya  N.P. ( 1998 ) ,  Molecular diagnosis of myotonic dystrophy and  Huntington's disease from Calcutta, India. Neurology India, 46, 199-203

37. Pandit B and Bhattacharyya N.P. (1998) Detection of telomerase activity in Chinese hamster V79 cells and its inhibition by 7-deaza-deoxy guanosine triphosphate and (TTAGGG)4, Biohem.Biophys. Res. Commun. 251, 620-624

38. Basu, P., Gangopadhaya, P. K , Mukherjee, S.C. ,  Sinha, K. K.  and Bhattacharyya, N.P (1998) Expansion of CTG repeat in myotonin protein    kinase gene on Alu ( ins ) - Hinf1-1 background  in a myotonic dystrophy patient  from  India , Human Mutation, 13, 79

39. Phear, G., Bhattacharyya, N. P. and Meuth, M. ( 1996 ) Loss of heterozygosity and base substitution at the APRT locus in mismatch repair proficient and deficient colorectal carcinoma cell lines, Mol. Cell Biol., 16, 6516-6523

40. Zhang, H., Tsujimura, T., Bhattacharyya, N. P., Maher, V. M. and McCormick, J. J. (1996) O6 - methylguanine induces intrachromosomal homologous recombination in human cells, Carcinogenesis, 17, 2229-2235

41. Ghosh, R., Sengupta, S. and Bhattacharyya, N. P. ( 1996 ) Induction of apoptosis by ionizing radiation in chinese hamster V79 cells and a radioresistant cell strain derived from V79,  Indian J. Expt. Biol., 34, 863-867.

42. Sengupta, S. and Bhattacharyya, N. P. (1996) Oxidative stress induced cadmium resistance in Chinese hamster V79 cells, Biochem. Biophys. Res. Commun. 228,  267-271

43. Bhattacharyya, N. P. and Meuth, M. (1995) Mutational pathways in colorectal Carcinoma cell lines, Indian J. Human Genet. 1, 87-92

44. Groden J., Joslyn, G., Samwitz, W., Jones, D., Bhattacharyya , N.P., Spirio, L., Thliveris, A., Robertson, M, Egan, S., Meuth, M. and White, R. ( 1995) Response of colon cancer cell lines to the introduction of APC, a colon specific tumor suppressor gene , Cancer Research, 55, 1531-1539

45. Bhattacharyya, N. P., Ganesh, A., Phear, G., Richards, B., Skandalis, A. and Meuth, M. (1995) Molecular analysis of mutations in mutator colorectal carcinoma cell lines, Hum. Mol. Genet., 4, 2057-2064

46. Bhattacharyya, N. P., Skandalis, A., Ganesh, A., Groden, J. and Meuth, M. (1994) Mutator phenotypes in human colorectal carcinoma cell lines, Proc. Natl. Acad. Sci. USA, 91, 6319-6323

47. Harwood, J., Tachibana, A., Davies, R., Bhattacharyya, N. P., and Meuth, M. (1993) High rate of APRT allele loss in human tumour cell line, Human Molecular Genetics, 2, 165-171

48. Roy (Pal), M.,  Sen Gupta, S., Ghosh, R., Bhattacharyya, N. P.,  Dey, S. K. and Bhattacharjee, S. B. ( 1993) Characterisation of the methotrexate resistant cells, Mutat. Res. , 291, 43-51

49. Roy (Pal), M., Sen Gupta, S., Bhattacharyya, N. P., Dey, S. K. and Bhattacharjee, S. B. (1993) Response of MTX- resistant cells to some DNA damaging agents, Mutat. Res., 285, 199-207

50. Chaudhuri, S.,  Sen Gupta, S., Bhattacharyya, N. P. and Bhattacharjee, S. B. ( (1992 ) Effect of hydrogen peroxide on mammalian chromatin : electonmicroscopic studies, J. Electron Micros., 41, 261-263

51. Chaudhuri, S.,  Bhattacharyya, N. P. and Bhattacharjee, S. B. (1992 ) Hydrogen peroxide induced DNA damages in vitro revealed by electron microscopy, J. Electron Micros. 41, 57-59

52. Lahiri, A., Chauduri, S. and Bhattacharyya, N. P. (1992) Theoretical analysis of gel electrophoretic data for interaction of lycine rich histone with supercoiled DNA, Biophysical Chemistry, 42, 223-228

53. Bhattacharyya, N. P., Maher, V. M. and MacCormick, J. J. (1990) Effects of nucleotide excision repair in human cells on intrachromosomal homologous recombination induced by UV and 1-nitrosopyrene, Mol. Cell Biol., 10, 3945-3951

54. Bhattacharyya, N. P., Maher, V. M. and MacCormick, J. J. (1990) Intrachromosomal homologous recombination in human cells which differ in nucleotide excision repair capacity, Mutat. Res., 234, 31-41

55. Maher, V. M., Domoradzki, J., Bhattacharyya, N. P., Tsujimura, T., Coner, R. C. and MacCormick, J. J. (1990) Alkylation damage, DNA repair and mutagenesis in human cells, Mutation Research, 233, 235-245

56. Bhattacharyya, N. P., Maher, V. M. and MacCormick, J. J. (1989) Ability of structurally related polycyclic aromatic carcinogens to induce homologous Mutat. Res., 211, 205-214

57. Maher, V. M., Patton, J. D., Aust, A. E., Bhattacharyya, N. P. and MacCormick, J. J. (1987) Mutations and homologous recombination induction in mammalian cells by metabolites of Benzo(a)pyrine and 1-nitrosopyrene, Environ. Health Persp., 76, 33-39

58. Bhattacharjee, S. B., Bhattacharyya N. P. and Chatterjee, S. (1987) Influence of caffeine on X-ray induced killing and mutation in V79 cells, Radiat. Res., 109, 310-318

59. Bhattacharjee, S. B. and Bhattacharyya, N. P. (1986) Influence of inhibitors of poly (ADP-ribose) polymerase activity on X-rays and ultraviolet light induced killing and mutation in Chinese hamaster V79 cells, Carcinogenesis, 7, 1267-1271

60. Bhattacharyya, N. P., and Bhattacharjee, S. B. (1986) Effect of nicotinamide on N-methyll-N'-nitro-N-nitrosoguanidine induced killing and mutation, Chem. Biol. Interact., 60, 287-295

61. Bhattacharyya, N. P., and Bhattacharjee, S. B. (1985) Interaction of UV and N-methyl-N'- nitro-N-nitrosoguanidine: cytotoxicity and mutagenicity in V79 cells, Mutat. Res., 152, 77-83

62. Chatterjee, S. , Bhattacharjee, S. B., Bhattacharyya, N. P. and Bhowmick, G., ( 1984 ) UV non-mutable mutant from V79 Chinese hamster cells, Mol. Gen. Genet., 193, 251-254

63. Bhattacharjee, S. B., Chatterjee, S., Bhattacharyya, N. P. (1984) Modification of X-ray induced lethality and mutation in V79 cells by caffeine treatment, Indian J. Phys., 58A, 316-322

64. Bhattacharyya, N. P. and Bhattacharjee, S. B. (1983) Suppression of N-methyl-N'-nitro- N-nitrsoguanidine induced mutation in V79 cells by inhibition of poly (ADP-ribose) polymerase activity, Mutat. Res., 121, 287- 292

In Monographs

1. Bhattacharyya, N. P. and Bhattacharjee, S. B. (1985) Poly (ADP-ribose) polymerase inhibition and the induction of mutation in V79 cells. In: ADP- Ribosylation of Proteins (eds. Althaus, F. R., Hilz, H. and Shall, S. ) pp337-341. Springer Verlag, Berlin

2. Maher, V. M., Wang, Y., Bhattacharyya, N. P., MacCormick, J. J. and Liskey, R. M. (1987) Carcinogen induced homologous recombination in mammalian cells. In: Mammalian Cell mutagenesis, Banbury Report, 28, (eds. Moore, M. M., DeMarini, D. M., de Serres, F. and Tindall, K. R.) pp 355-363. Cold Spring Harbour Laboratory Press, New York

3. Maher, V. M., Bhattacharyya, N. P., Mah, Chia-Miao, M., Boldt, J., Yang, Jia-Ling, and MacCormick, J. J. ( 1987 ) Mutations induced by 1-nitrosopyrene and related compounds during DNA replication in human cells and induction of homologous recombination by these compounds, Health Effects Institute Research Report No. 55

4. Bhattacharyya, N. P., Dasgupta, S. and Bhattacharjee, S. B. (1989) Killing and mutation of density inhibited V79 cells as affected by inhibition of poly (ADP- ribose) synthesis. In: ADP-Ribose Transfer Reactions-Mechanisms and Biological Significance (eds. Jacobson, M. K. and Jacobson, E. L. ) pp 261-269. Sprnger-Verlag, Berlin

5. Maher, V. M., Bhattacharyya, N. P., Wang, Y., Tsujimura, T., Liskey, R. M., Godwin, A. and MacCormick, J. J. ( 1990 ) Role of DNA damage and excision repair in intrachromosomal homologous recombination between duplicated genes in mammalian cells, including repair proficient and deficient human cells. In: Ionising Radiation Damage to DNA: Molecular Aspects (eds. Wallace, S. and Painter, R.) pp 181-191. Wiley & Sons, New York

6. Maher, V. M., Bhattacharyya, N. P., Wang, Y., Tsujimura, T., Liskey, R. M., Godwin, A. and MacCormick, J. J. (1990) Carcinogens induced homologous recombination between duplicated genes stability integrated within the genome of mammalian cells including normally repairing and repair deficient human cells. In: Genetic Mechanisms of Carcinogenesis and Tumour Progression (eds. Harris, C. and Liotta, L.) pp 53-57. Wiley & Sons, New York

7. Bhattacharyya, N. P., MacCormick, J. J. and Maher, V. M. (1990) Induction of intrachromosomal homologous recombination in mammalian cells including nucleotide excision repair profecient and defecient human cells. In : Environmental Mutagenesis and Carcinogenesis ( ed. Chauhan, P. S. ) pp7-15 EMSI, Bombay

8. Bhattacharyya, N. P.,  Choudhuri, S. and Bhattacharjee, S. B. ( 1991 ) Comparison of DNA damage induced by hydrogen peroxide in the presence of various metal in vitro. In: Proceedings of the symposium on Environment and Genome (ed. S. B. Bhattacharjee ) pp 387-394

9. Roy, M., Bhattacharyya, N. P., Dey, S. K. and Bhattacharjee, S. B. ( 1991 ) Gene amplification : loss of genetic stability in V79 cells, Ibid, pp336-341

10. Bhattacharyya, N. P., Ghosh, R., Sengupta, S.,Choudhuri, S., Roy, M. and Bhattacharjee, S. B. ( 1991 ) Inhibition of potentially lethal and mutagenic damage repair in Chinese hamster cells. Ibid, pp203-413.

11. Maher, V. M., Mah, M. C. M., Yang, J. L., Bhattacharyya, N. P. and MacCormick, J. J. ( 1991 ) Muatations and homologous recombination induced by N-substituted aryl compounds in mammalian cells. In: Nitroarenes : Occurence, Metabolism and Biological Impacts ( ed. Howard, P. C. ) pp 149-156. Plenum Publishing Corp., New York.

12. Roy M., Sengupta S., Bhattacharyya N.P. and Bhattacharjee S.B. (1998) Mutation and sisterchromatid exchanges in gene amplified V79 cells. In: Environmental Mutagenesis and Carcinogenesis. Vol. 3 (eds. P.S. Chauhan and P.M. Gopinath) pp 39-47. Quest Publications, Mumbai.

13. Pandit B and Bhattacharyya, N.P. (1998) Radiation resistance in a cell strain     derived from Chinese hamster V79 cells. In: Trends in Radiation and Cancer Biology ( ed. R.N.Sharan ) Forschungszentrum  Julich GmbH Germany , pp104-110

14. Pandit B, Bhaumik G. and Bhattacharyya N. P. (1999) Mutator phenotype in a Chinese hamster cell strain?  In: Recent aspects of cellular and applied radiobiology (eds. Schneeweiss F.H.A. and Sharan R. N.), Forschungszentrum  Julich GmbH , Germany. Pp 165-169).

15. Bhattacharyya N. P. (1999) Molecular methods for identification of genes and mutations: with special reference to neurodegenerative disorders spinocerebellar ataxia. In Advances in Clinical Neurosciences, Volume 9 (Eds. Sinha K.K and Chandra P) The Catholic Press, Ranchi, India. Pp 323-337.

16. Baksi K, Nag N., Chakraborty H., Sen U. and Bhattacharyya NP (2005) Polymorphic amino acid substitutions: predictions for possible functional alteration. pp 133-141. In Proceedings of the International Seminar on Frontiers of Basic and Applied Molecular Biology (eds. Poddar RK et al.) Department of Biophysics, Molecular Biology and Genetics.

17. Chattopadhyay B. Baksi K., Majumder P. and Bhattacharyya NP (2005) Genetic Modifiers in Huntington’s disease and Spinocerebellar ataxia type 2. pp 37-49, In the Proceedings of the International Seminar on Frontiers of Basic and Applied Molecular Biology (eds. Poddar RK et al.), Department of Biophysics Molecular Biology and Genetics

18. Chattopadhyay B. Baksi K., Majumder P. and Bhattacharyya NP (2005) Molecular Genetics and Biology of poly glutamine expansion diseases. pp 270-282. In Molecular and Cellular Neurobiology (Eds. Thakur MK and Prasad S), Narosa Publishing House, New Delhi.