• Proteomics, Protein Interactomics

  • Molecular Basis of Neurodegenerative disorders

  • Structural Biology

  • Molecular Phylogenetics

  • M.Sc. in Biophysics, Molecular Biology & Genetics (1995), University of Calcutta

  • Ph. D. in Protein Crystallography (2000), Saha Institute of Nuclear Physics

  • Post-Doctoral Research Associate (2000 - 03), Skaggs Fellowship, Dept. of Molecular & Experimental Medicine, The Scripps Research Institute, La Jolla, USA

  • Post-Graduate Research Scientist (2004 - 05), School of Medicine, University of California at San Diego, USA

  1. Samanta D, Mukhopadhyay D, Chowdhury S, Ghosh J, Pal S, Basu A, Bhattacharya A, Das A, Das D, Dasgupta C. "Protein folding by domain V  of E. coli 23S rRNA: Specificity of RNA-protein interactions." J Bacteriol. 2008 Feb 29; [Epub ahead of print]

  2. Sucharita Dey, Swasti Raychaudhuri, N. P. Bhattacharyya & Debashis Mukhopadhyay. “The Role of Intrinsically Disordered Proteins In Neurodegenerative Diseases”.Annals of Neurosciences (2007), Vol. 14 (Suppl.), 58-59. (Abstract only)

  3. Swasti Raychaudhuri, Mithun Sinha, Debashis Mukhopadhyay, N.P. Bhattacharyya. "HYPK, a huntingtin interacting protein, reduces aggregates and apoptosis induced by N-terminal huntingtin with 40 glutamines in Neuro2A cells and exhibits chaperone like activity".  Hum. Mol. Gen (2008). Jan 15;17(2):240-55.

  4. Swasti Raychaudhuri, Pritha Majumder, Somosree Sarkar, Kalyan Giri, Debashis Mukhopadhyay and Nitai P. Bhattacharyya. "INTRINSICALLY UNSTRUCTURED proteins in Huntington’s disease - HYPK: a case study".  Proteins: Structure, Function & Bioinformatics (2007); Dec 12 [Epub ahead of print]

  5. Raychaudhuri M., Mukhopadhyay D.,(2007) "AICD AND ITS ADAPTORS - IN SEARCH OF NEW PLAYERS", Journal of Alzheimer's Disease, Volume 11, Number 3. 343-58.

  6. Dipankar Bhattacharyya, Debashis Mukhopadhyay and Abhijit Chakrabarti (2007). Hemoglobin depletion from red blood cell cytosol reveals new proteins in 2D gel based proteomics study. Proteomics – Clinical Applications.  1, 561-564.

  7. Majumder P, Chattopadhyay B, Sukanya S, Ray T, Banerjee M, Mukhopadhyay D, Bhattacharyya NP  (2007) Interaction of HIPPI with putative promoter sequence of caspase-1 in vitro and in vivo.Biochem Biophys Res Commun , 353, 80-85.

  8. Dewji, N.N., Mukhopadhyay, D., Singer, S.J. (2006) An early specific cell-cell interaction occurs in the production of β-amyloid in cell cultures. Proc. of Nat. Acad. of Sc. USA 103 (5), pp. 1540-1545.

  9. Mukhopadhyay, D., Varughese, K.I. (2005) A computational analysis on the specificity of interactions between histidine kinases and response regulators. Jr  Biomolecular Str.  Dyn. 22 (5), pp. 555-562.

  10. N.N.Dewji, D.Mukhopadhyay, S.Singer (2004) A β-APP:PS MEDIATED INTERCELLULAR INTERACTION IS REQUIRED FOR AT LEAST THE MAJOR PART OF Aβ PRODUCTION. Program No. 23.14. 2004 Abstract Viewer. Washington, DC: Society for Neuroscience, 2004. Online.

  11. D.Mukhopadhyay, D.A.Valdez, N.N.Dewji (2004) ON THE MECHANISM OF  γ-SECRETASE CLEAVAGE OF β-APP TO PRODUCE Aβ. Program No. 146.12. 2004 Abstract Viewer. Washington, DC: Society for Neuroscience, 2004. Online.

  12. Debashis Mukhopadhyay, Udayaditya Sen, James Zapf and Kottayil I. Varughese, (2004) Metals in the sporulation phosphorelay: manganese binding by the response regulator SpoOF. Acta Crystallographica D, 60(4), 638-45.

  13. Mukhopadhyay, D. (2000) The molecular evolutionary history of a winged bean α-chymotrypsin inhibitor and modeling of its mutations through structural analyses. Journal of Molecular Evolution 50 (3), pp. 214-223.

  14. J. Dasgupta, S. Ravichandran, D. Mukhopadhyay, U.Sen, A. Podder, C. Chakrabarti and J.K.    Dattagupta (1999).  A Serine Protease Inhibitor Protein : From X-ray Structure to Protein Engineering.   In Volume  published in honour of Prof. G.N. Ramachandran during International Biophysics Congress at New Delhi in September, 1999. Book name: “Perspectives in Structural Biology” Editors:M.Vijayan, N.Yathindra, A.S.Kolaskar, Page 75-82.

  15. Dattagupta, Jiban K., Podder, Aloka, Chakrabarti, Chandana, Sen, Udayaditya, Mukhopadhyay, Debashis, Dutta, Samir K. and Singh, Manoranjan (1999). Refined Crystal Structure (2.3 Å) of a Double-Headed Winged Bean a-Chymotrypsin Inhibitor and Location of Its Second Reactive Site. PROTEINS : Structure, Function, and Genetics, 35(3), 321-331.

  16. Debashis Mukhopadhyay and Jiban K. Dattagupta (1999). Synchrotron radiation in Molecular Biology.  Science & Culture , May-June, 128-132.

Contact: debashis.mukhopadhyay[at]saha.ac.in

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