• Membrane Biophysics (Organization, transbilayer asymmetry and distribution of cell surface membrane proteins and lipids)
  • Membrane Skeleton (spectrin-based network, spectrin and its ligand binding, chaperone-activity, interaction with hemoglobin variants, globin chains in hemoglobinopathy)
  • Protein folding (assisted folding using skeletal proteins and phosphatidylethanolamine)
  • Fluorescence Spectroscopy (time-resolved and steady-state measurements)
  • Electron Microscopy and Flow Cytometry (cell biology of red cell membrane proteins, skeletal proteins of Thalassemic & Leukemic blood cells).
  • Proteomics in blood disorders (Red cells and B cell proteomics, implications in Leukemia and Thalassemia, analysed by 2DGel Electrophoresis and MALDI-ToF/ToF technique)

 

Masters : Calcutta University.

PhD : Indian Institute of Science.

PostDoc : The Johns Hopkins University, Baltimore.

Faculty : Biophysics Division and Structural Genomics Section

Head : Centre for Advanced Research & Education

  1. Dipankar Bhattacharya, Sutapa Saha, Sumanta Basu, Sudipa Chakravarty, Amit Chakravarty, Debashis Banerjee and Abhijit Chakrabarti. Differential regulation of redox proteins and chaperones in erythrocyte proteomes in HbEb-thalassemia. (2010). Proteomics – Clinical applications. in press. 

  2. Sumanta Basu, Debasis Banerjee, Sarmila Chandra and Abhijit Chakrabarti. Eryptosis in hereditary spherocytosis and thalassemia : role of glycoconjugates. (2010). Glycoconjugate Journal. in press.

  3.  Abhijit Chakrabarti, Poppy Datta, Dipankar Bhattacharya, Sumanta Basu, Sutapa Saha. Oxidative Crosslinking, Spectrin and Membrane Interactions of Hemoglobin Mixtures in HbEb-thalassemia. (2008). Hematology. 13, 361-368.

  4.  Debasis Banerjee, Sumanta Basu, Sutapa Saha and Abhijit Chakrabarti. Porous red cell ultrastructure and loss of membrane asymmetry in a novel case of hemolytic anemia. (2008). Eur. J. Haematol. 81, 399-402.

  5. Sumanta Basu, Debasis Banerjee, Sarmila Chandra and Abhijit Chakrabarti. Loss of phospholipid membrane asymmetry and sialylated glycoconjugates from erythrocyte surface in HbEb-thalassemia. (2008). Brit. J. Haematol. 141, 92-99. 

  6. Poppy Datta, Sudipa Chakrabarty, Amit Chakrabarty and Abhijit Chakrabarti. Membrane interactions of hemoglobin variants, HbA, HbE, HbF and globin subunits of HbA : effects of aminophospholipids and cholesterol. (2008). Biochim. Biophys. Acta 1778, 1-9.

  7. "Spectrin interactions of globin chains in presence of phosphate metabolites and hydrogen peroxide: Implications in thalassemia". Poppy Datta, Sudipa Chakrabarty, Amit Chakrabarty and Abhijit Chakrabarti. J Biosci. 32 (2007); 1147-1151.

  8. Dipankar Bhattacharyya, Debashis Mukhopadhyay and Abhijit Chakrabarti.  Hemoglobin depletion from red blood cell cytosol reveals new proteins in 2D gel based proteomics study.  (2007). Proteomics – Clinical Applications.  1, 561-564.

  9. Abhijit Chakrabarti, Devaki A. Kelkar and Amitabha Chattopadhyay. Spectrin Organization and Dynamics: New Insights. (2006). BioSci Rep. 26, 369-386.

  10. Durjoy Majumdar, Debasis Banerjee, Sharmila Chandra Subir Banerjee & Abhijit Chakrabarti. Red Cell Morphology in Leukemia, Hypoplastic Anemia and Myelodysplastic Syndrome. (2006). Pathophysiology 13, 217-225.

  11. Malyasri Bhattacharyya, Chaitali Mukhopadhyay & Abhijit Chakrabarti. Specificity of Prodan for the self-associating domain of spectrin : A molecular docking study. (2006). J. Biomol. Struc. Dyn. 24, 269-276.

  12. Poppy Datta, Sumanta Basu, Sudipa Basu Chakrabarty, Amit Chakrabarty, Debasis Banerjee, Sharmila Chandra & Abhijit Chakrabarti. Enhanced oxidative cross-linking of hemoglobin E with spectrin and loss of erythrocyte membrane asymmetry in hemoglobin Eb-Thalassemia. (2006). Blood Cells, Molecules & Diseases. 37, 77-81.

  13. Devaki A Kelkar, Amitabha Chattopadhyay, Abhijit Chakrabarti and Malyasri Bhattacharyya. Effect of ionic strength on the organization and dynamics of tryptophan residues in erythroid spectrin : A fluorescence approach. (2005). Biopolymers, 77, 325-334.

  14. Sibnath Ray, Malyasri Bhattacharyya & Abhijit Chakrabarti. Conformational study of spectrin in presence of submolar concentrations of denaturants. (2005). J Fluorescence 15, 61-70.

  15. Malyasri Bhattacharyya, Sibnath Ray, Shekhar Bhattacharya & Abhijit Chakrabarti. Chaperone activity and Prodan binding at the self-associating domain of erythroid spectrin. (2004). J Biol Chem. 279, 55080-55088.

  16. Udayaditya Sen, Jhimli Dasgupta, Debi Choudhury, Poppy Datta, Abhijit Chakrabarti, Sudipa Basu Chakrabarty, Amit Chakrabarty and Jiban K. Dattagupta. Crystal structures of HbA2 and HbE and modeling of hemoglobin d4 : interpretations of the thermal stability and antisickling effect of HbA2 and identification of the ferrocyanide binding site in Hb. (2004). Biochemistry 43, 12477-12488.

  17. Mosumi Mandal and Abhijit Chakrabarti. Effect of the glycosphingolipid, GM1 on localization of dibucaine in phospholipid vesicles : a fluorescence study. (2004). Chem. Phys. Lipids 130, 175-187.

  18. Sibnath Ray and Abhijit Chakrabarti. Membrane interaction of erythroid spectrin : Surface-density-dependent high affinity binding to phosphatidylethanolamine. (2004). Mol. Memb. Biol. 21, 93-100.

  19. Amitabha Chattopadhyay, Satinder S Rawat, Devaki A Kelkar, Sibnath Ray and Abhijit Chakrabarti. Organization and dynamics of tryptophan residues in erythroid spectrin : Novel structural features of denatured spectrin revealed by the wavelength-selective fluorescence approach. (2003). Protein Sci. 12, 2389-2403.

  20. Mousumi Mandal, Abhijit Chakrabarti and Soumen Basak. Photophysical study of local anesthetics in reverse micelles. (2003). J Fluorescence 13, 307-314.

  21. Poppy Datta, Sudipa Basu Chakrabarty, Amit Chakrabarty and Abhijit Chakrabarti. Interaction of erythroid spectrin with hemoglobin variants : Implications in beta-Thalassemia. (2003). Blood Cells Mol Dis. 30, 248-253.

  22. Jhimli Dasgupta, Udayaditya Sen, Debi Choudhury, Poppy Datta, Abhijit Chakrabarti, Sudipa Basu Chakrabarty, Amit Chakrabarty and J. K. Dattagupta. Crystallization and preliminary X-ray structural studies of Hemoglobin A2 and Hemoglobin E, isolated from the blood samples of b-thalassemic patients. (2003). Biochem. Biophys. Res. Commun. 303, 619-623.

  23. Dilip Debnath, Shekhar Bhattacharya and Abhijit Chakrabarti. Phospholipid assisted folding of a denatured heme protein : Effect of phosphatidylethanolamine. (2003). Biochem Biophys Res Commun. 301, 979-984.

  24. Sibnath Ray and Abhijit Chakrabarti. Erythroid spectrin in miceller detergents. (2003). Cell Motil. Cytoskeleton 54, 16-28.

  25. Mousumi Mandal and Abhijit Chakrabarti. The tertiary amine local anesthetic, Dibucaine binds to the membrane skeletal protein, spectrin. (2002). FEBS Lett. 532, 396-400.

  26. Abhijit Chakrabarti, Shekhar Bhattacharya, Sibnath Ray and Malyasri Bhattacharyya. Binding of a denatured heme protein and ATP to erythroid spectrin. (2001). Biochem. Biophys. Res. Commun. 282, 1189-1193.

  27. Soumen Basak, Dilip Debnath, Emdadul Haque, Sibnath Ray and Abhijit Chakrabarti. Structural perturbation of proteins in low denaturant concentrations. (2001). Ind. J. Biochem. Biophys. 38, 84-89.

  28. Mosumi Mandal, Kasturi Mukhopadhyay, Soumen Basak, and Abhijit Chakrabarti. Effect of cholesterol on interaction of dibucaine with phospholipid vesicles: a fluorescence study. (2001). Biochim. Biophys. Acta 1511, 146-155.

  29. Md. Emdadul Haque, Sibnath Ray and Abhijit Chakrabarti. Polarity estimate of the hydrophobic binding sites in erythroid spectrin : A stydy by pyrene fluorescence. (2000). J. Fluorescence. 10, 1-6.

  30. Abhijit Chakrabarti and Shekhar Bhattacharya. Spectrin exhibits chaperone-like activity. (1999). Curr. Sci. 77, 812-813.

  31. Abhijit Chakrabarti, Aloke K Bera, Biswadip Das, Subrata Chattopadhyay, Dibyendu Sarkar and Chanchal Dasgupta. Binding and conformation of denatured horseradish peroxidase during E. coli ribosome mediated folding. (1999). Curr. Sci. 76, 1235-1238.

  32. Sangita Majee and Abhijit Chakrabarti. Membrane Interaction of the antitumor antibiotic, Mithramycin, in liposomes containing anionic phospholipids. (1999). Biochem. Pharmacol. 57, 981-987.

  33. Sangita Majee, Dipak Dasgupta and Abhijit Chakrabarti. Interaction of the DNA-binding antitumor antibiotics chromomycin and mithramycin with erythroid spectrin. (1999). Eur. J. Biochem. 260, 619-626.

  34. Tapobrata Lahiri, Niladri S. Kar, Abhijit Chakrabarti and Anjan Kumar Dasgupta. Onset of percolation and fractal classification scheme for multilamellar lipid vesicles. (1999). J. Col. Int. Sci. 211, 89-95.

  35. Md. Emdadul Haque, Dilip Debnath, Soumen Basak and Abhijit Chakrabarti. Structural changes in horseradish peroxidase in presence of low concentrations of urea. (1999). Eur. J. Biochem. 259, 269-274.

  36. Tapobrata Lahiri, Abhijit Chakrabarti and Anjan Kumar Dasgupta. Multilamellar vesicular clusters of phosphatidylcholine and their sensitivity to spectrin : a study by fractal analysis. (1998). J. Struct. Biol. 123, 179-186.

  37. Debashis Pal, Subrata Chattopadhyay, Suparna Chandra, Dibyendu Sarkar, Abhijit Chakrabarti and Chanchal Dasgupta. Reactivation of denatured proteins by the domain V of bacterial 23S ribosomal RNA. (1997). Nucleic Acid Res. 25, 5047-5051.

  38. T.S. Ramlingam, Abhijit Chakrabarti and Michael Edidin. Interaction of class I human leukocyte antigen (HLA-I) with insulin receptors and its effect on the insulin-signalling cascade. (1997). Mol. Biol. Cell. 8, 2463-2474.

  39. Jayanti Guharay, Rupali Chaudhuri, Abhijit Chakrabarti and Pradeep K Sengupta. Excited State Proton Transfer Fluorescence of 3-hydroxyflavone in Model Membranes. (1996). Spectrochim. Acta. Part A (Biomolecular spectroscopy section). 53, 457-462.

  40. Tapobrata Lahiri, Anjan K Dasgupta and Abhijit Chakrabarti. Patterns of Large Multilameller Vesicular Clusters. (1996). Curr. Sci. 71, 915-918.

  41. Abhijit Chakrabarti and Soumen Basak. Structural Alterations of Horseradish Peroxidase in the  Presence of Low Concentrations of Guanidinium Chloride. (1996). Eur. J. Biochem. 241, 462-467.

  42. Abhijit Chakrabarti. Fluorescence of Spectrin-Bound PRODAN. (1996). Biochem. Biophys. Res. Commun. 226, 495-497.

  43. Sangita Majee and Abhijit Chakrabarti. A DNA-binding antitumor antibiotic binds to spectrin. (1995).Biochem. Biophys. Res. Commun. 212, 428-432.

  44. Abhijit Chakrabarti, Subrata Chattopadhyay and C K. DasGupta. Partial unfolding of lactate dehydrogenase in the presence of low concentrations of guanidinium chloride. (1995). Curr. Sci. 68, 836-839.

  45. Abhijit Chakrabarti and Michael Edidin. Lateral association of class I major histocompatibility complex (MHC) molecules and insulin receptor in liposomes. (1992). Biophys. J. 61, A147.

  46. Abhijit Chakrabarti, Janos Matko, Noorul A. Rahman, B. George Barisas and Michael Edidin. Self-association of class I major histocompatibility complex (MHC) molecules in liposome and cell surface membranes. (1992). Biochemistry. 31, 7182-7189.

  47. Abhijit Chakrabarti and S. K. Podder. Complex carbohydrate lectin interaction at the interface : A model for cellular adhesion II. Reactivity of both the oligosaccharide chain and sugar-binding domain of a glycoprotein lectin. (1992). J. Mol. Recognition. 5, 67-71.

  48. Abhijit Chakrabarti and Sunil K. Podder. Lectin binding to complex carbohydrate at the interface : A study by resonance energy transfer.(1992). Ind. J. Biochem. Biophys. 29, 262-265.

  49. Abhijit Chakrabarti and S.K. Podder. Complex carbohydrate lectin interaction at the interface : A model for cellular adhesion I. Effect of vesicle-size on the kinetics of aggregation between fatty acid conjugate of lectin and liposomal asialoganglioside. (1990). Biochim. Biophys. Acta. 1024, 103-110.

  50. S.K.Podder, A.Chakrabarti, K.Vijayalakshmi and P. Lalit. K. Singh. Liposome-bearing gangliosides : Model membrane system for studying the molecular mechanism of cell surface carbohydrate-mediated processes. (1988). Ind. J. Biochem. Biophys. 25, 156-165.

  51. S.K.Podder, A.Chakrabarti, K.Vijayalakshmi and P. Lalit. K. Singh. Reactivity of glycoconjugates in membrane system II : Can a neutral glycolipid function as lectin receptor in the presence of gangliosides in plasma membrane. (1987). J. BioSci. 11, 495-502.

Contact: abhijit.chakrabarti[at]saha.ac.in

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